| Year | Performing artist | Work | Nominees | Ref. |
| 1980 | Wings | |
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| 1981 | The Police | | Dixie Dregs – Dregs of the Earth Emerson, Lake & Palmer – "Peter Gunn" Jean-Luc Ponty – "Beach Girl" The Pretenders – "Space Invader" | |
| 1982 | The Police | | Dixie Dregs – Unsung Heroes Robert Fripp – The League of Gentlemen Kraftwerk – "Computer World" Rush – "YYZ" | |
| 1983 | A Flock of Seagulls | | Dixie Dregs – Industry Standard Maynard Ferguson – "Don't Stop 'til You Get Enough" King Crimson – "Requiem" Van Morrison – "Scandinavia" | |
| 1984 | Sting | | Allan Holdsworth – Road Games Rainbow – "Anybody There" Pete Townshend – "Unused Piano: 'Quadrophenia'" Stevie Ray Vaughan & Double Trouble – "Rude Mood" | |
| 1985 | Yes | | Genesis – "Second Home by the Sea" Lionel Hampton – "Vibramatic" Edward Van Halen – "Donut City" Stevie Ray Vaughan & Double Trouble – "Voodoo Child (Slight Return)" | |
| 1986 | | | Big Guitars from Texas – "Guitar Army" The Jon Butcher Axis – "The Ritual" Yngwie Malmsteen – Rising Force Northern Star – "Back to Earth" Stevie Ray Vaughan & Double Trouble – "Say What!" | |
| 1987 | Art of Noise featuring Duane Eddy | | The Fabulous Thunderbirds – "Down at Antone's" Eric Johnson – "Zap" The Alan Parsons Project – "Where's the Walrus?" Yes – "Amazing Grace" | |
| 1988 | | | Herbie Hancock with Dweezil Zappa & Terry Bozzio – "Wipe Out" Bruce Springsteen & the E Street Band – "Paradise by the 'C'" Stevie Ray Vaughan & Dick Dale – "Pipeline" Stevie Ray Vaughan & Double Trouble - "Say What!" | |
| 1989 | | | The Jeff Healey Band – "Hide Away" Jimmy Page – "Writes of Winter" Joe Satriani – Surfing with the Alien Frank Zappa – Guitar | |
| 1990 | | | Steve Morse – High Tension Wires Joe Satriani – "The Crush of Love" Andy Summers – "A Piece of Time" Stevie Ray Vaughan & Double Trouble – "Travis Walk" | |
| 1991 | Jimmie Vaughan & Stevie Ray Vaughan | | The Allman Brothers Band – "True Gravity" Eric Johnson – Ah Via Musicom Joe Satriani – Flying in a Blue Dream Steve Vai – Passion and Warfare | |
| 1992 | | | The Allman Brothers Band – "Kind of Bird" Danny Gatton – 88 Elmira St. Rush – "Where's My Thing?" Yes – "Masquerade" | |
| 1993 | & Double Trouble | | Jeff Beck & Jed Leiber – "Hound Dog" Dixie Dregs – Bring 'Em Back Alive Santana – "Gypsy/Grajonca" Joe Satriani – The Extremist | |
| 1994 | | | Aerosmith – "Boogie Man" Jeff Beck & Jed Leiber – "Hi-Heel Sneakers" Joe Satriani – "Speed of Light" Tangerine Dream – "Purple Haze" | |
| 1995 | Pink Floyd | | Dixie Dregs – "Shapes of Things" Rush – "Leave That Thing Alone" Carlos Santana, Jorge Santana & Carlos Hernandez – "Luz Amore y Vida" Joe Satriani – "All Alone" | |
| 1996 | The Allman Brothers Band | | The Jeff Healey Band – "Shapes of Things" King Crimson – "Vrooom" Santana with Vernon Reid – "Every Now and Then" Steve Vai – "Tender Surrender" | |
| 1997 | , Eric Clapton, Bonnie Raitt, Robert Cray, B.B. King, Buddy Guy, Dr. John & Art Neville | | Booker T. & the M.G.'s – "Green Onions" Eric Johnson – "Pavilion" Joe Satriani – "(You're) My World" Edward Van Halen & Alex Van Halen – "Respect the Wind" | |
| 1998 | The Chemical Brothers | | Robben Ford – "In the Beginning" Eric Johnson – "S.R.V." Joe Satriani – "Summer Song" Steve Vai – "For the Love of God" | |
| 1999 | Pat Metheny Group | | Everclear – "El Distorto de Melodica" Propellerheads – "Take California" Joe Satriani – "A Train of Angels" Kenny Wayne Shepherd Band – "Trouble Is..." Jimmie Vaughan – "The Ironic Twist" | |
| 2000 | Santana featuring Eric Clapton | | Jeff Beck – "What Mama Said" Green Day – "Espionage" Moby – "Bodyrock" Steve Vai – "Windows to the Soul" | |
| 2001 | Metallica with the San Francisco Symphony | | Peter Frampton – "Off the Hook" Phish – "First Tube" Joe Satriani – "Until We Say Goodbye" Kenny Wayne Shepherd Band – "Electric Lullaby" | |
| 2002 | | | The Allman Brothers Band – "High Falls" Godsmack – "Vampires" Joe Satriani – "Always with Me, Always with You" Steve Vai – "Whispering a Prayer" | |
| 2003 | The Flaming Lips | | Gov't Mule – "Sco-Mule" Tony Levin – "Apollo" Joe Satriani – "Starry Night" Slash – "Love Theme from The Godfather" | |
| 2004 | | | The Allman Brothers Band – "Instrumental Illness" Linkin Park – "Session" Robert Randolph & the Family Band – "Squeeze" Steve Vai – "Essence" | |
| 2005 | | | The Allman Brothers Band – "Instrumental Illness" Los Lonely Boys – "Onda" Rush – "O Baterista" Steve Vai – "Whispering a Prayer" | |
| 2006 | & Friends | | Adrian Belew – "Beat Box Guitar" Stewart Copeland – "Birds of Prey" Joe Perry – "Mercy" Steve Vai – "Lotus Feet" | |
| 2007 | The Flaming Lips | | Arctic Monkeys – "Chun-Li's Spinning Bird Kick" Peter Frampton – "Black Hole Sun" David Gilmour – "Castellorizon" Joe Satriani – "Super Colossal" | |
| 2008 | | | Metallica – "The Ecstasy of Gold" Rush – "Malignant Narcissism" Joe Satriani – "Always with Me, Always with You" Steve Vai – "The Attitude Song" | |
| 2009 | Zappa Plays Zappa featuring Steve Vai & Napoleon Murphy Brock | | David Gilmour – "Castellorizon" Metallica – "Suicide & Redemption" Nine Inch Nails – "34 Ghosts I–IV" Rush – "Hope " | |
| 2010 | | | Booker T. Jones – "Warped Sister" Brad Paisley – "Playing with Fire" The Brian Setzer Orchestra – "Mr. Surfer Goes Jazzin'" Steve Vai – "Now We Run" | |
| 2011 | | | The Black Keys - "Black Mud" Los Lobos – "Do the Murray" Dave Matthews & Tim Reynolds – "Kundalini Bonfire" Dweezil Zappa – "The Deathless Horsie" | |