William Giles
William Giles and Bill Giles may refer to:
- Bill Giles (American football), head football coach at Chadron State College Fort Hays State University
- Bill Giles (baseball), longtime Philadelphia Phillies executive and part owner
- Bill Giles (meteorologist), meteorologist and television presenter
- William Giles (colonial manager), CEO of the South Australia Company, 1841–1860, and member of the South Australian colonial legislature
- William Giles (Oz), fictional character on HBO's prison drama Oz, played by Austin Pendleton
- William B. "Buck" Giles, American baseball player
- William Branch Giles, American statesman
- William Fell Giles, U.S. Representative from Maryland
- William Henry Giles Kingston, writer of tales for boys
- William L. Giles, president of Mississippi State University, 1966–1976