Charles Best

• Charles Best (poet), English poet
• Charles Best (British Army officer), British army officer
• Charles Best (American football), American college football and basketball coach
• Charles Best (medical scientist), American-Canadian medical scientist and co-discoverer of insulin
• Charles Best (politician), Australian politician
• Charles Best (businessman), American businessman and founder of Donorschoose.org
• Charles Alexander Best, Canadian politician, son of Charles Herbert Best