Petty thief Nick Robey botches a robbery, leaving his partner Al severely wounded as Nick escapes with over $10,000. Meeting bakery worker Peg Dobbs in friendly conversation, when Peg takes Nick to her family's apartment, he decides to take the family hostage until he can escape. As a manhunt for Nick begins outside, the robber becomes increasingly paranoid. Peg's initial attraction to Nick is overwhelmed by his abusive behavior. Her mother and father plead with Nick to leave, to no avail. He permits Mr. Dobbs to leave for work, warning him of the consequences should the police be contacted. Still confident that Peg will run away with him, Nick gives her $1,500 to buy a new car. He refuses to believe her when Peg returns and insists the car will be delivered to the front door because she doesn't drive. Nick violently drags her down the stairs toward the exit, terrifying her. Waiting outside is her father, shooting at Nick with a gun. When his own gun drops beyond his reach and Nick orders Peg to hand it to him, she shoots him instead. A mortally wounded Nick crawls outside to the curb, just as his new car arrives.
When the film was released, film criticBosley Crowther praised the work of actor John Garfield, writing: "John Garfield's stark performance of the fugitive who desperately contrives to save himself briefly from capture is full of startling glints from start to end. He makes a most odd and troubled creature, unused to the normal flow of life, unable to perceive the moral standards of decent people or the tentative advance of a good girl's love. And in Mr. Garfield's performance, vis-a-vis the rest of the cast, is conveyed a small measure of the irony and the pity that was in the book." More recently, film critic Dennis Schwartz also wrote positively of Garfield's performance, writing: "He Ran All the Way was the last film made by the brilliant John Garfield... Garfield gives a terrific chilling performance as someone who is less like a cold-bloodedkiller than someone who has been rejected all his life by family and the outside world, and like a wounded animal goes on the run as a desperate man in search of someone to trust in this cold world."