Heterogeneity of epidermal growth factor binding kinetics on individual cells
Heterogeneity of epidermal growth factor binding kinetics on individual cells is a scholarly work, published in 1997 in ''Biophysical Journal''. The main subjects of the publication include chemistry, fluorescence recovery after photobleaching, biophysics, fluorescence microscope, epidermal growth factor, cell, kinetics, fluorescein, G protein-coupled recepteishon, Autofluorescence, fluorescence, heterogeneity, binding site, photobleaching, Receptor-ligand kinetics, and monoclonal antibody therapy. Model simulations and the results from data analysis indicate that the one-monovalent-site model does not describe EGF binding kinetics at the single-cell level, whereas the two-site model is consistent with, but not proved by, the single-cell binding data.