1-Aminopropan-2-ol
1-Aminopropan-2-ol is the organic compound with the formula CH3CHCH2NH2. It is an amino alcohol. The term isopropanolamine may also refer more generally to the additional homologs diisopropanolamine and triisopropanolamine.
1-Aminopropan-2-ol is chiral. It can be prepared by the addition of aqueous ammonia to propylene oxide.Biosynthesis
-1-Aminopropan-2-ol is one of the components incorporated in the biosynthesis of cobalamin. The O-phosphate ester is produced from threonine by the enzyme Threonine-phosphate decarboxylase.Applications
The isopropanolamines are used as buffers. They are good solubilizers of oil and fat, so they are used to neutralize fatty acids and sulfonic acid-based surfactants.
Racemic 1-aminopropan-2-ol is typically used in metalworking fluid, waterborne coatings, personal care products, and in the production of titanium dioxide and polyurethanes. It is an intermediate in the synthesis of a variety of pharmaceutical drugs.
-1-aminopropan-2-ol is metabolised to aminoacetone by the enzyme -aminopropanol dehydrogenase.
