James Duke
James Duke may refer to:
- James [Buchanan Duke], American tobacco and electric power magnate
- *SS James B. Duke a Liberty ship
- James A. Duke, ethnobotanist
- Sir James Duke, [1st Baronet], British Member of Parliament
- Sir James Duke, 2nd Baronet, of the Duke baronets
- James "Red" Duke, Houston, Texas, doctor
- James Duke (footballer), Scottish footballer