James Sweeney
James Sweeney may refer to:
- James Johnson Sweeney, museum curator
- James Joseph Sweeney, American, Roman Catholic bishop
- James Sweeney (film editor), American film editor
- James Sweeney (Medal of Honor), Union Army soldier during the American Civil War
- James Sweeney (filmmaker), American screenwriter, director, and actor
- James G. Sweeney, Nevada attorney general and justice of the Supreme Court of Nevada
- James R. Sweeney II, American attorney
- James M. Sweeney, healthcare entrepreneur
- James Sweeney (architect), American architect
- James Monroe Sweeney, American baseball umpire