John Semple

• John Semple (minister), Ulster-Scots Presbyterian minister and Scots Worthy
• John Semple (architect), Irish architect
• John Semple (footballer), Scottish footballer
• Jock Semple, Scots-American sports official and trainer
• John Greenlees Semple, British mathematician
• John Semple (civil servant), former head of the Northern Ireland Civil Service
• John W. Semple, Canadian medical researcher
• John C. Semple, American botanist