Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design is a scholarly work, published in 2012 in ''Journal of pharmaceutics''. The main subjects of the publication include transdermal patch, matrix, xyloglucan, chromatography, granulation, mucosal immune system, materials science, polysaccharide, polymer, response surface methodology, carboxymethyl cellulose, drug delivery, mathematics, and chemistry. The formulated tablets showed anomalous release mechanism and followed matrix drug release kinetics, resulting in regulated and complete release from the tablets within 8 to 10 hours.