Padmore was Worcester's first non-conformist mayor—rejecting a procession to the cathedral or his place of worship and refusing to wear a mayoral robe—from 1849 to 1849, and from 1852 to 1853 before being elected Liberal MP for Worcester at a by-election in 1860—caused by the resignation of William Laslett. He held the seat until 1868 when he did not seek re-election.