Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution
Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution is a scholarly work by Robyn Ward, Zoltán Szállási, Nicholas McGranahan, Eva Gronroos, Peter Gibbs, Nicholas J. Hawkins, Oliver Sieber, Charles Swanton, Sally M Dewhurst, David Endesfelder, Rebecca Burrell, and Tejal Joshi, published in 2014 in ''Cancer Discovery''. The main subjects of the publication include Genome evolution, oncogenomics, genome instability, biology, polyploidy, genome, computational biology, whole genome sequencing, chromosome instability, and genetics. The authors use long-term culture of isogenic tetraploid cells from a stable diploid colon cancer progenitor to investigate how a genome-doubling event affects genome stability over time.