William Best

• William Best (cricketer), English cricketer
• William Thomas Best, English organist
• William Best, 1st Baron Wynford, British politician and judge
• William Best, 2nd Baron Wynford, British peer
• William Best (Nova Scotia politician), Nova Scotia politician, one of the founders of Halifax
• William Best, composed the music for the song "(I Love You) For Sentimental Reasons"
• Willie Best, American television and film actor