William Bruce
William Bruce may refer to:
- Sir William Bruce (architect), Scottish architect
- William Bruce, 8th Earl of Kincardine, Scottish nobleman
- William Bruce (cricketer), Australian cricketer
- William Bruce (Canadian politician), physician and politician in Upper Canada
- William Bruce (VC), posthumous recipient of the Victoria Cross
- William Cabell Bruce, author and United States Senator
- Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
- William Speirs Bruce, Scottish explorer
- William George Bruce, Milwaukee publisher, historian, and civic leader
- William Bruce (minister, born 1757), Irish Presbyterian and educator
- William Bruce (minister, born 1790), Irish Presbyterian and professor
- William Blair Bruce, Canadian painter
- William Napier Bruce, British educationalist and lawyer
- William J. Bruce III, American author and publicist