William Cheyne

• William Cheyne (died 1420), MP for Dorset (UK Parliament constituency)
• William Cheyne (15th century MP) for Kent
• William Cheyne (judge), English Chief Justice, 1424–1438
• Sir William Cheyne, 1st Baronet, British surgeon and bacteriologist
• William Cheyne, 2nd Viscount Newhaven, MP for Amersham, Appleby and Buckinghamshire
• William Cheyne (footballer), Scottish footballer for Rangers