YqeY protein domain


In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase in almost all eukaryotes.

Function

The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine. In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis. However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.

Homology

This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.