S'Yan: The uncle of T'Challa and the brother of T'Chaka.
Shuri: T'Challa's sister. She has taken up the role of Black Panther and is current ruler of Wakanda after T'Challa was badly injured by Doctor Doom.
Allies
Ramonda: T'Challa's caring stepmother and biological mother of Shuri.
Monica Lynne: A singer who saved T'Challa from drowning after being bested by Killmonger. His longest love interest, whom he pledged eternal devotion towards. They later drifted apart though Lynne was genuinely saddened to hear that T'Challa was marrying Storm. She would later die from cancer, but not before seeing her former lover one final time.
Everett K. Ross: A U.S. State Department employee, whose job was to escort foreign diplomats on American soil. His world changed forever when he was assigned to T'Challa, the Black Panther, the ruler of Wakanda.
N'Gassi: Adviser to T'Challa, acting regent when he goes away on missions.
Okoye: One of the former Dora Milaje, a ceremonial betrothed/bodyguard of T'Challa. Okoye is of the J'Kuwali tribe and acted as a traditional, proper concomitant to the king, speaking only to the king and only in Hausa, an African language widely spoken in Wakanda and thus affording the king and his wives a measure of privacy.
Queen Divine Justice: Ce'Athauna Asira Davin is the street-smart queen of the Jabari tribe of Wakanda raised in Chicago, and former Dora Milaje of T'Challa. She originally went by the name Chanté Giovanni Brown.
Storm: Ororo Iqadi T'Challa, a member of the X-Men; she was the Black Panther's wife and Queen of Wakanda but the marriage was later annulled.
W'Kabi: T'Challa's competent second-in-command, completely loyal to his liege.
Zuri: A grumpy and gigantic elderly warrior. A close friend of the late T'Chaka, and one of T'Challa's most trusted advisers.
Azari: Son of Black Panther and Storm and future Black Panther from the Earth-555326 timeline.
Antagonists
Achebe : A poor farmer somewhere in South Africa, Achebe sold his soul to the demonMephisto. He is portrayed as a grinning, unpredictable, lunatic, warrior-mystic, regularly talking to his hand-puppet Daki with delusions that it is truly alive.
Erik Killmonger: A powerful warrior and strategic genius in politics and economics.
Kiber the Cruel: A scientist who gained the ability to absorb the psionic consciousness/life forces of human beings.
Klaw: Murderer and betrayer of T'Chaka and enemy of T'Challa who can control sound.
Kraven the Hunter: A hunter who has fought Black Panther on occasion.
Malice: Wakandan mutate with superhuman strength, speed, and agility. She is a former Dora Milaje of T'Challa.
Man-Ape: Ruler of the Jabari Tribe, a recognized micronation within Wakanda's borders. Founding member of the "Pan African Congress on the Treatment of Superhumans".
Venomm: A man who can control the behavior of snakes through training, chemicals, and apparently some form of psionic influence
White Wolf: T'Challa's adopted elder brother and the former leader of the Hatut Zeraze, the espionage elite police of Wakanda.
Windeagle: A villain who wears an anti-gravity costume which enabled him to fly and glide on wind currents.
